Intervertebral disc characterization by shear wave elastography: an in-vitro preliminary study

Patient-specific numerical simulation of the spine is a useful tool both in clinic and research. While geometrical personalization of the spine is no more an issue, thanks to recent technological advances, non-invasive personalization of soft tissue’s mechanical properties remains a challenge. Ultrasound elastography is a relatively recent measurement technique allowing the evaluation of soft tissue’s elastic modulus through the measurement of shear wave speed (SWS). The aim of this study was to determine the feasibility of elastographic measurements in intervertebral disc (IVD). An in-vitro approach was chosen to test the hypothesis that SWS can be used to evaluate IVD mechanical properties and to assess measurement repeatability. Eleven oxtail IVDs were tested in compression to determine their stiffness and apparent elastic modulus at rest and at 400 N. Elastographic measurements were performed in these two conditions and compared to these mechanical parameters. The protocol was repeated six times to determine elastographic measurement repeatability. Average SWS over all samples was 5.3 ± 1.0 m/s, with a repeatability of 7 % at rest and 4.6 % at 400 N; stiffness and apparent elastic modulus were 266.3 ± 70.5 N/mm and 5.4 ± 1.1 MPa at rest, respectively, while at 400 N they were 781.0 ± 153.8 N/mm and 13.2 ± 2.4 MPa. Correlations were found between elastographic measurements and IVD mechanical properties; these preliminary results are promising for further in-vivo application.The authors are grateful to the ParisTech BiomecAM chair program on subject-specific musculoskeletal modelling for funding (with the support of Proteor, ParisTech and Yves Cotrel Foundations)

3D reconstruction of ribcage geometry from biplanar radiographs using a statistical parametric model approach

Rib cage 3D reconstruction is an important prerequisite for thoracic spine modelling, particularly for studies of the deformed thorax in adolescent idiopathic scoliosis. This study proposes a new method for rib cage 3D reconstruction from biplanar radiographs, using a statistical parametric model approach. Simplified parametric models were defined at the hierarchical levels of rib cage surface, rib midline and rib surface, and applied on a database of 86 trunks. The resulting parameter database served to statistical models learning which were used to quickly provide a first estimate of the reconstruction from identifications on both radiographs. This solution was then refined by manual adjustments in order to improve the matching between model and image. Accuracy was assessed by comparison with 29 rib cages from CT scans in terms of geometrical parameter differences and in terms of line-to-line error distance between the rib midlines. Intra and inter-observer reproducibility were determined regarding 20 scoliotic patients. The first estimate (mean reconstruction time of 2’30) was sufficient to extract the main rib cage global parameters with a 95% confidence interval lower than 7%, 8%, 2% and 4° for rib cage volume, antero-posterior and lateral maximal diameters and maximal rib hump, respectively. The mean error distance was 5.4 mm (max 35mm) down to 3.6 mm (max 24 mm) after the manual adjustment step (+3’30). The proposed method will improve developments of rib cage finite element modeling and evaluation of clinical outcomes.This work was funded by Paris Tech BiomecAM chair on subject specific muscular skeletal modeling, and we express our acknowledgments to the chair founders: Cotrel foundation, Société générale, Protéor Company and COVEA consortium. We extend your acknowledgements to Alina Badina for medical imaging data, Alexandre Journé for his advices, and Thomas Joubert for his technical support

Analysis of Center of Mass and Gravity-Induced Vertebral Axial Torque on the Scoliotic Spine by Barycentremetry

STUDY DESIGN: Retrospective observational study. OBJECTIVES: To determine the mass distribution along the scoliotic trunk using barycentremetry and its relationship with vertebral axial rotation and torque. SUMMARY OF THE BACKGROUND DATA: Deformity progression in adolescent idiopathic scoliosis (AIS) is not yet fully understood, but gravity load on the spine could play a role. Barycentremetry allows to characterize body mass distribution in standing position, which could provide a better understanding the mechanisms of progression. METHODS: 81 subjects (27 healthy adolescents and 53 AIS patients) underwent biplanar radiography and 3D reconstruction of the spine and body envelope. Position of the gravity line was estimated, as well as trunk segmental centers of mass COMs at each vertebral level and resulting axial torques to each vertebra. RESULTS: The COM of all trunk segments was less than 1 cm from the gravity line in the frontal plane for healthy subjects, and less than 1.5 cm for AIS patients. Vertebral axial torque was 0.7 ± 0.5 Nm in healthy subjects, 2.9 ± 2.1 Nm at the junctional vertebrae of AIS patients and 0.5 ± 0.5 at the apex. A strong association was found between high torque and high intervertebral rotation at junctions, with low torque and low intervertebral axial rotation at the apex. CONCLUSION: Results suggest that AIS patients can maintain the COM of each body segment close to their gravity line, irrespective of the severity and asymmetry of their deformity. Moreover, torque analysis shed some light on the importance of junctional vertebrae in the spinal deformity and, potentially, in the vicious cycle determining scoliosis progression. LEVEL OF EVIDENCE: Level III.The authors are grateful to the ParisTech BiomecAM chair program on subject-specific musculoskeletal model- ling (with the support of ParisTech and Yves Cotrel Foundations, Société Géenérale, Proteor, and Covea

Vertebral rotation estimation from frontal X-rays using a quasi-automated pedicle detection method

Purpose Measurement of vertebral axial rotation (VAR) is relevant for the assessment of scoliosis. Stokes method allows estimating VAR in frontal X-rays from the relative position of the pedicles and the vertebral body. This method requires identifying these landmarks for each vertebral level, which is time-consuming. In this work, a quasi-automated method for pedicle detection and VAR estimation was proposed. Method A total of 149 healthy and adolescent idiopathic scoliotic (AIS) subjects were included in this retrospective study. Their frontal X-rays were collected from multiple sites and manually annotated to identify the spinal midline and pedicle positions. Then, an automated pedicle detector was developed based on image analysis, machine learning and fast manual identification of a few landmarks. VARs were calculated using the Stokes method in a validation dataset of 11 healthy (age 6–33 years) and 46 AIS subjects (age 6–16 years, Cobb 10°–46°), both from detected pedicles and those manually annotated to compare them. Sensitivity of pedicle location to the manual inputs was quantified on 20 scoliotic subjects, using 10 perturbed versions of the manual inputs. Results Pedicles centers were localized with a precision of 84% and mean difference of 1.2 ± 1.2 mm, when comparing with manual identification. Comparison of VAR values between automated and manual pedicle localization yielded a signed difference of − 0.2 ± 3.4°. The uncertainty on pedicle location was smaller than 2 mm along each image axis. Conclusion The proposed method allowed calculating VAR values in frontal radiographs with minimal user intervention and robust quasi-automated pedicle localization.The authors are grateful to the ParisTech BiomecAM chair program on subject-specific musculoskeletal modeling for funding (with the support of ParisTech and Yves Cotrel Foundations, Société Générale, Proteor and Covea)

Rib Cage Measurement Reproducibility Using Biplanar Stereoradiographic 3D Reconstructions in Adolescent Idiopathic Scoliosis

Study design: A reproducibility study of preoperative rib cage 3D measurements was conducted for patients with Adolescent Idiopathic Scoliosis (AIS). Objective: to assess the reliability of rib cage 3D reconstructions using biplanar stereoradiography in patients with AIS before surgery. Summary: no prior reliability study has been performed for preoperative 3D reconstructions of the rib cage by using stereoradiography in patients with preoperative AIS. Materials: this series includes 21 patients with Lenke 1 or 2 scoliosis (74°+ - 20). All patients underwent low-dose standing biplanar radiographs. Two operators performed reconstructions twice each. Intraoperator repeatability, interoperator reproducibility and Intraclass coefficients (ICC) were calculated and compared between groups. Results: The average rib cage volume was 4.7l L (SD ± 0.75 L). SDr was 0.19 L with a coefficient of variation of 4.1% ; ICC was 0.968. The thoracic index was 0.6 (SD ± 0.1). SDr was 0.03 with a coefficient of variation of 4.7 % and a ICC of 0.820. As for the Spinal Penetration Index (6.4% ; SD ± 2.4), SDr was 0.9 % with a coefficient of variation of 14.3 % and a ICC of 0.901. The 3D rib hump SDr (average 27° ± 8°) was 1.4°. The coefficient of variation and ICC were respectively 5.1% and 0.991. Conclusion: 3D reconstruction of the rib cage using biplanar stereoradiography is a reliable method to estimate preoperative thoracic parameters in patients with AIS

A convolutional neural network to detect scoliosis treatment in radiographs

Purpose The aim of this work is to propose a classification algorithm to automatically detect treatment for scoliosis (brace, implant or no treatment) in postero-anterior radiographs. Such automatic labelling of radiographs could represent a step towards global automatic radiological analysis. Methods Seven hundred and ninety-six frontal radiographies of adolescents were collected (84 patients wearing a brace, 325 with a spinal implant and 387 reference images with no treatment). The dataset was augmented to a total of 2096 images. A classification model was built, composed by a forward convolutional neural network (CNN) followed by a discriminant analysis; the output was a probability for a given image to contain a brace, a spinal implant or none. The model was validated with a stratified tenfold cross-validation procedure. Performance was estimated by calculating the average accuracy. Results 98.3% of the radiographs were correctly classified as either reference, brace or implant, excluding 2.0% unclassified images. 99.7% of brace radiographs were correctly detected, while most of the errors occurred in the reference group (i.e. 2.1% of reference images were wrongly classified). Conclusion The proposed classification model, the originality of which is the coupling of a CNN with discriminant analysis, can be used to automatically label radiographs for the presence of scoliosis treatment. This information is usually missing from DICOM metadata, so such method could facilitate the use of large databases. Furthermore, the same model architecture could potentially be applied for other radiograph classifications, such as sex and presence of scoliotic deformity.Acknowledgements The authors are grateful to the ParisTech BiomecAM chair program on subject-specific musculoskeletal modelling (with the support of ParisTech and Yves Cotrel Foundations, Société Générale, Proteor and Covea)

Trunk Growth in Early-Onset Idiopathic Scoliosis Measured With Biplanar Radiography

Study Design Cross-sectional and longitudinal retrospective study. Objectives To measure thoracic dimensions and volume during growth in early-onset idiopathic scoliosis (EOIS) patients and to compare them to a population of asymptomatic adults and to the previous literature. Summary of Background Data Data on trunk growth for scoliotic children between 6 and 14 years of age is sparse in the literature. Methods Thirty-six patients (29 girls and 7 boys, between 3 and 14 years old, average Cobb angle 33°±15°) were included, all with a minimum two-year follow-up. Sixty-one asymptomatic girls and 54 asymptomatic adults were included as control groups. All subjects underwent biplanar radiography and 3D reconstruction of the spine, pelvis, and rib cage. EOIS patients repeated their radiologic examination every six months. Cobb angle, rib cage volume, anteroposterior and transverse diameters, thoracic index, thoracic perimeter, pelvic incidence, and T1–T12 and T1–S1 distance were calculated. Reproducibility of measurement was assessed. Results Measurement reliability in such young patients was comparable to previous studies in adolescents and adults. Geometrical parameters of EOIS patients increased linearly with age. For instance, rib cage volume in girls with EOIS increased from 2200 cm3 at six to seven years of age to 4100 cm3 at 13–14 years (65% of adult values, 294 cm3/y). Comparison with asymptomatic girls showed that EOIS could affect growth spurt. Longitudinal analysis on a cohort of six girls who had a follow-up of six years confirmed the cross-sectional data. Conclusions In this longitudinal and cross-sectional study, trunk growth between 3 and 14 years of age was characterized, for the first time, with biplanar radiography and 3D reconstruction. The results can be useful to estimate patient growth and thus have potential application in the surgical planning of EOIS patients. Level of Evidence Level II, retrospective study

An Integrated Framework to Achieve Interoperability in Person-Centric Health Management

The need for high-quality out-of-hospital healthcare is a known socioeconomic problem. Exploiting ICT's evolution, ad-hoc telemedicine solutions have been proposed in the past. Integrating such ad-hoc solutions in order to cost-effectively support the entire healthcare cycle is still a research challenge. In order to handle the heterogeneity of relevant information and to overcome the fragmentation of out-of-hospital instrumentation in person-centric healthcare systems, a shared and open source interoperability component can be adopted, which is ontology driven and based on the semantic web data model. The feasibility and the advantages of the proposed approach are demonstrated by presenting the use case of real-time monitoring of patients' health and their environmental context

Normal Range of Patellar Tendon Elasticity Using the Sharewave Elastography Technique: An In Vivo Study in Normal Volunteers

In-vivo investigation of tendon mechanical properties in healthy subjects using Shear Wave Elastography (SWE) techniques is a relatively new field of study. This work aims to evaluate the elastic properties of the patellar tendon in various knee range of flexion. Twenty healthy adult subjects were enrolled in the study. Shear wave speed (SWS) in the patellar tendon was measured in three different positions: Knee extended, knee semi-flexed (30°), and knee flexed (90°). Mean shear modulus was 50.9 +- 33.1 kPa in knee extension position, 137.5 +- 50.7 kPa in 30° flexion position, and 226.5 +- 60.3 kPa in 90° flexion position. The lowest shear modulus was obtained at rest with the knee in a fully extended position. These results are in agreement with those previously reported on Achilles tendon and triceps muscles. Shear modulus values obtained in our study could be considered as baseline values for further investigations in adults

Contribution of shear wave elastography in evaluation of the deltoid in reverse shoulder arthroplasty: reproducibility study and preliminary results

Aims: The current difficulty of reverse shoulder arthroplasty (RSA) is soft tissue management, and adequate deltoid tension and at present there is no consensus and available tools (X-ray, MRI, EMG) remain difficult to apply in clinical follow-up. The objective of this study was (1) to determine reliability and feasibility of deltoid elasticity assessment using ultrasound elastographyand (2) to assess the change of deltoid stiffness after RSA by comparing shear wave speed (SWS) between healthy and RSA shoulders. Material and methods: Twenty-six healthy (native shoulder, painless and complete range of motion) subjects and twelve patients with RSA were included. Two independent investigators performed 3 measurements on each segment. Measurements were bilateral. Anterior segment was also evaluated at 45° and 60° of passive abduction. Reliability and feasibility have been assessed (ISO5725-standard). Results: Coefficient of measurements variation was less than 6.1% and 0.13 m/s. In the healthy group, SWS was not significantly different between anterior and middle segments; however, the SWS of the posterior segment was significantly lower than others (p<0.0001). In abduction position, compared to the rest position, SWS of the anterior segment decreased at 45° abduction (p=0.0003) and increased at 60° abduction (p<0.0001). Variability of measurement was higher in the RSA group. No significant difference was found between the SWS measurement of the operated and non-operated side. SWS measurements of the operated side of the anterior and middle segment were significantly higher compared to the healthy group. In abduction position, compared to rest position, no difference in SWS of the anterior segment was found at 45° abduction (p=0.71) and nor at 60° abduction (p=0.75). Conclusion: This study demonstrated feasibility and reliability of shoulder assessment with shear wave elastography. Reference values for asymptomatic patients can already be used in future studies on shoulder pathology and surgery